SAMHD1 and cancer: For instance, the impact of SAMHD1 on cell proliferation presents a controversial picture: SAMHD1 knockdown inhibits the proliferation of Hela and MCF7 cells,[15] while its depletion in THP‐1 cells promotes proliferation and reduces apoptosis.[16] Considering SAMHD1's involvement in diverse cellular processes, such as regulating dNTP pools, maintaining genomic stability, participating in DNA repair, and immune modulation, further research is needed to better understand its role in cancer, including hepatocellular carcinoma.[17]