To investigate the role of hepatic SAMHD1 in the initiation and progression of HCC, we generated mice with hepatocyte‐specific conditional SAMHD1 knockout (HKO) by crossing SAMHD1flox/flox mice with mice expressing hepatocyte‐specific Cre recombinase (CreAlb). The gene discussed is SAMHD1; the disease is hepatocellular carcinoma.