Our study reveals a novel role of SAMHD1 in regulating cell cycle progression in hepatoma cells, extending beyond its known function as a dNTPase in maintaining cell cycle stability.[45] The effect of SAMHD1's catalytic activity on cellular dNTP levels varies by cell type; while silencing SAMHD1 raises dNTP levels in non‐replicating monocyte‐derived macrophages,[46] it has minimal impact in dividing HEK293T cells.[22] In HepG2 cells, SAMHD1 overexpression does not reduce dNTP levels, suggesting alternative mechanisms in its inhibition of cell proliferation. Here, SAMHD1 is linked to hepatocellular carcinoma.