This modification is crucial for the function of oncogenes (such as neuroblastoma RAS viral (v‐ras) oncogene and epidermal growth factor receptor) and tumor suppressors (such as scribble planar cell polarity protein and melanocortin 1 receptor).[53] Our findings affirm that the COOH‐terminal domain of DRD4 is essential for its pro‐metastatic function in CRC, potentially through its association with the palmitoylation site. Here, MC1R is linked to colorectal carcinoma.