INS and type 2 diabetes mellitus: More recently, the multicenter, parallel-group, open-label LUCID trial (Liberal Glucose Control in Critically Ill Patients with Preexisting Type 2 Diabetes trial) of 419 adult patients with T2DM admitted to the ICU and randomized into the intervention group (which received intravenous insulin when blood glucose was > 252 mg/dL and titrated to a target range of 180–252 mg/dL) and the comparator group (insulin initiated at a blood glucose >180 mg/dL and titrated to a target range of 108–180 mg/dL)52.