CD4 and uveitis: Unfortunately, further comparison between autoimmune and virus models is complicated by numerous factors; in the autoimmune encephalomyelitis and uveitis models, T cell activation is dependent on immunization with self-peptide or antigen in adjuvant resulting in the induction of both Th1 and Th17 CD4 T cells (11, 33), whereas virus-specific T cells are activated by replicating virus and presentation of viral antigen generating an exclusive Th1 response (17, –, 20).