IFNG and neoplasm: During immunotherapy, activated CD8+ T cells promote tumor cell ferroptosis by secreting IFNγ to reduce the expression of SLC7A11 and increase the expression of ACSL4 in tumor cells.[27, 28] Lipro‐1, an inhibitor of ferroptosis, significantly inhibited the efficacy of immunotherapy,[27, 28] suggesting that ferroptosis is one of the mechanisms by which immunotherapy suppresses tumors.