We found that erastin or RSL3 or IR treatment increased mitophagy in a time‐ and concentration‐dependent manner in HCT116 and MDA‐MB‐231 cancer cells, as shown by decreased protein levels of the mitochondrial proteins TOM20 and TIMM23 and decreased mitochondrial DNA (mtDNA) (Figure3A,B; Figure S2A–H, Supporting Information). This evidence concerns the gene TIMM23 and cancer.