HIF1A and breast cancer: reported that BNIP3 deficiency‐mediated mitophagy defects enhanced Hif‐1α stabilization by increasing mitochondrial ROS, thereby promoting lung metastasis of breast cancer cells.[16] BRCA1 deficiency‐mediated mitophagy defects promoted breast cancer cells to secrete IL‐1β by activating the NLRP3 inflammasome, which then promoted macrophage differentiation to the M2 phenotype, leading to CD8+ T cell inactivation, and ultimately enhancing breast cancer lung metastasis.[17] These studies suggest that defective mitophagy is an important factor driving the malignant progression of certain tumors.