In addition, in terms of structure and function, CAFs can provide a fertile environment for tumor growth by secreting extracellular matrix ECM protein, epidermal growth factor (EGF)/fibroblast growth factor, pro-angiogenic factor, platelet-derived growth factor (PDGF), chemokines and other factors (Zhang J. et al., 2020). The gene discussed is EGF; the disease is neoplasm.