IL1B and periodontitis: The bone formation/resorption balance goes through the regulation of pyroptosis and it is known that NLRP3 is able to produce IL-1β and trigger pyroptosis in response to molecular patterns associated with periodontal pathogens; however, an inappropriate activation of the inflammasome, may generate an environment prone to inflammation and massive cell destruction, as occurs in the bone destruction characteristic of periodontitis (Chen Q. et al., 2021).