Polymerase chain reaction (PCR), used for the detection of periodontal pathogens in aggressive periodontitis, showed an increase of IL-1β, produced by macrophages and monocytes, in early stages of inflammation, which would signify the important role of local inflammation on systemic inflammation (Noack et al., 2001; Ebersole et al., 2002; Salzberg et al., 2006; Lopez-Castejon and Brough, 2011). The gene discussed is IL1B; the disease is periodontitis.