Furthermore, they found a positive correlation of NLRP3 levels, together with certain metabolic parameters, including glucose, aspartatetransferase and alaninetransferase levels, demonstrating that chronic hepatitis C and periodontal disease could significantly influence the up-regulation of NLRP3 and its components, possibly contributing to an increased local inflammatory reaction (Surlin et al., 2021). This evidence concerns the gene NLRP3 and periodontal disorder.