The bone formation/resorption balance goes through the regulation of pyroptosis and it is known that NLRP3 is able to produce IL-1β and trigger pyroptosis in response to molecular patterns associated with periodontal pathogens; however, an inappropriate activation of the inflammasome, may generate an environment prone to inflammation and massive cell destruction, as occurs in the bone destruction characteristic of periodontitis (Chen Q. et al., 2021). This evidence concerns the gene NLRP3 and periodontitis.