When A549 cells infected with ZIKV at an MOI of 0.1 were treated with the PIM1 inhibitor SGI-1776, both the intracellular envelope protein level and the RNA level of ZIKV were markedly suppressed by SGI-1776 in a dose-dependent manner at 48 h post-infection (Figures 7A, B). This evidence concerns the gene ERVW-1 and infection.