For example, apoptosis signal-regulating kinase 1 (ASK1) phosphorylates histone deacetylase 6 (HDAC6) and inhibits the ubiquitin−mediated proteolysis of HDAC6, which contributes to the pathology induced by oxygen changes, suggesting a potential target for the treatment of retinopathy of prematurity (Ran et al., 2020). This evidence concerns the gene MAP3K5 and retinal disorder.