Albumin (ALB), glucose (GLU), triglyceride (TAG), total cholesterol (T-CHO), low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acid (NEFA) contents and alkaline phosphatase (ALP), alanine amino transferase (ALT) activity in hemolymph were significantly affected by dietary substitution of FO with CSO (P < 0.05). The gene discussed is ALB; the disease is craniosynostosis.