Moreover, the previously reported correlation between the greater iloprost-induced ATP release from RBCs isolated from humans with T2DM compared to healthy subject and HbA1c levels (Sprague et al., 2010), which is a modified hemoglobin species that exhibits secondary structure alterations (Ye et al., 2016), may support our proposed relationship between the altered Hb and hypoxia-induced ATP release from RBCs in ApoE/LDLR−/− mice. Here, GSTM1 is linked to type 2 diabetes mellitus.