PANX1 and atherosclerosis: The results of 3V-induced ATP release from RBCs experiments suggested that in our model of atherosclerosis the signal-transduction pathway is intact from the adenylyl cyclase activation step which leads to the release of ATP through PANX1 conduit, but that the activation of β-adrenergic receptors could be impaired due to either lowered expression or loss of sensitivity and/or the decreased Gs protein expression.