APOE and atherosclerosis: ApoE/LDLR double-knockout (ApoE/LDLR−/−) mice model shows impaired lipoprotein clearance and is a reliable animal model to investigate the atherosclerosis disease (Lo Sasso et al., 2016; Wojewoda et al., 2016; Bar et al., 2019; Dybas et al., 2020).