The former exerts pro-tumor effects by promoting tumor invasion, migration, and immunosuppression through factors such as vascular endothelial growth factor (VEGF), signal transducer and activator of transcription 3 (STAT3), transforming growth factor-β (TGF-β), and interleukin-10 (IL-10). The gene discussed is TGFB1; the disease is neoplasm.