The aberrantly active fatty acid oxidation (FAO) reaction in GBM can generate substantial quantities of acetyl Co-A to increase CD47 expression, which facilitates immune evasion through CD47 resistance to endocytosis and interference with FAO by etomoxir restores the endocytosis response of macrophages to tumors and also inhibits FAO-dependent MDSC and Tregs (31) (Figure 1). Here, CD47 is linked to glioblastoma.