demonstrated that in cells from patients with chronic myeloid leukemia, METTL3 in the nucleus is only responsible for transferring methyl groups to PES1 mRNA, while the enhancement of PES1 protein synthesis is the result of the action of METTL3 in the cytoplasm (59). Here, METTL3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.