The genes that were significant in the multivariate CPH model but were downregulated in the tumor compared to adjacent-normal tissues in the bulk RNA-seq were: ADCY5, FXYD2, CA2, ABCB4, SLC10A2, UGT2615, UGT2A3, SLC51B, ADCY4. The gene discussed is ADCY5; the disease is neoplasm.