CPSF6 and HIV-1 infection: Given that wild-type HIV-1 infection does not induce changes in APA to the same degree as CPSF6 knock-out in primary CD4+ T cells, we wanted to determine whether cell lines that undergo more significant changes in CPSF6 localization following HIV-1 infection exhibit greater disruption of CPSF6 function and changes in 3’ UTR length.