We found eleven AD GWAS genes (ALCAM, APP, COX7C, EGFR, GPC6, MYO15A, PLCG2, RTN1, SEC61G, SORL1, and TMEM106B) to be differentially expressed between the ancestries in the iOPC cluster (Fig. 3A, Table 3). Here, PLCG2 is linked to Alzheimer disease.