We found eleven AD GWAS genes (ALCAM, APP, COX7C, EGFR, GPC6, MYO15A, PLCG2, RTN1, SEC61G, SORL1, and TMEM106B) to be differentially expressed between the ancestries in the iOPC cluster (Fig. 3A, Table 3). Here, GPC6 is linked to Alzheimer disease.