We found eleven AD GWAS genes (ALCAM, APP, COX7C, EGFR, GPC6, MYO15A, PLCG2, RTN1, SEC61G, SORL1, and TMEM106B) to be differentially expressed between the ancestries in the iOPC cluster (Fig. 3A, Table 3). The gene discussed is TMEM106B; the disease is Alzheimer disease.