Age, BMI during the whole pregnancy, alanine aminotransferase (ALT), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), glucose in 1st trimester, insulin, C-peptide, fasting blood glucose (FBG) level during OGTT, FT4/TSH ratio, percentage of premature delivery and caesarean delivery were all significantly higher in GDM group than in NGT group. This evidence concerns the gene INS and gestational diabetes.