Moreover, Real-Time Quantitative Polymerase Chain Reaction analysis detected heightened expression of inflammatory markers such as lipopolysaccharide, apoptosis-associated speck-like protein, Caspase-1, Caspase-11, NLRP3, and interleukin -1β, alongside reduced levels of insulin receptor substrate-1 in T2DM patients (17). The gene discussed is NLRP3; the disease is type 2 diabetes mellitus.