However, different research groups have described that patients with classic obstetric clinical manifestations: (1) Are often intermittently seropositive for criteria aPL, (2) exhibit low titres of these antibodies, or (3) show persistent seropositivity for other autoantibodies that are not classically included in the diagnostic criteria for APS (e.g. aCL/vimentin complex antibodies, anti‐phosphatidylserine/prothrombin complex antibodies, anti‐phosphatidylinositol antibodies, anti‐phosphatidylcholine antibodies, anti‐sphingomyelin antibodies, among others).16, 17, 18, 19, 20. Here, ACLY is linked to autoimmune polyendocrinopathy.