According to these criteria, the persistent presence of moderate or high titres (titres > 99th percentile, at least in two occasions, at least 12 weeks apart) of aβ2GPI antibodies, anti‐cardiolipin (aCL) antibodies or lupus anticoagulant (LA) is a condition for APS diagnosis, both in its obstetric and vascular variants.14 This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.