CM has been shown to alter the hypothalamic–pituitary–adrenal (HPA) axis response to stress, leading to modified DNA methylation of the glucocorticoid receptor (NR3C1) and BDNF genes, which in turn increases susceptibility to schizophrenia (Barker et al., 2020; Figure 6D). The gene discussed is NR3C1; the disease is schizophrenia.