In the univariate logistics regression analysis, we found that SII, age, diabetic retinopathy, grade of hematuria, eGFR, serum albumin, serum creatinine, blood urea nitrogen, serum uric acid, total cholesterol, hemoglobin, urine RBC count and fibrinogen were respectively the risk factors of developing DN. The gene discussed is ALB; the disease is diabetic retinopathy.