In DN group, patients might had higher level of SII, diabetic retinopathy, serum creatinine, blood urea nitrogen, serum uric acid, total cholesterol, white blood cell, neutrophil, lymphocyte, monocyte, platelet, urine RBC count, urinary ACR, fibrinogen, CRP, PCT, and lower level of eGFR, serum albumin, hemoglobin, HbA1c, suggesting that DN group had more severe indicators when compared with DM group. This evidence concerns the gene CRP and diabetic retinopathy.