To determine how altered levels of APC5 and APC7 affect the sensitivity of cells to loss of KIF18A activity, the impact of co-depleting APC5 or APC7 with KIF18A was assessed in multiple immortalized cancer cell lines known to have varying sensitivity to depletion of KIF18A (Marquis, Fonseca et al. 2021, Payton, Belmontes et al. 2024). This evidence concerns the gene ANAPC5 and cancer.