ANAPC7 and Neurodevelopmental delay: In humans, a loss of function founder mutation in APC7 causes the Feguson-Bonni Neurodevelopmental Syndrome (FERBON) in a large pedigree of Amish ancestry; the clinical characteristics of FERBON include neurodevelopmental delay, locomotor deficits, and premature ovarian failure (Ferguson, Urso et al. 2022).