Although CMC alone (a common ingredient found in over-the-counter ocular lubricants used by dry eye patients) did not restore the BM, global RNAseq analysis following 24h of lubrication revealed an upregulation of BM associated genes such as Lama2, Col4a3, and Nid1, indicating the activation of BM regeneration occurs within this short time frame (Figure 1H). Here, COL4A3 is linked to Keratoconjunctivitis sicca.