In HeLa cells, co-overexpression of the mutants constructs and SYK followed by infection revealed that the mutated ITAM (Y650F; Y662F) significantly decreased FCRL3-dependent invasion, the mutated ITIM (Y692F) had no effect, and Y722F (within the ITIM-like/HemITAM motif) caused the same reduction in SYK-mediated invasion as the mutated ITAM construct (Fig. 5C). The gene discussed is FCRL3; the disease is infection.