The pirin-binding compounds TphA, CCT251236, CCG-257081, and related compounds reduce cancer cell proliferation, induce apoptosis, and synergize with known anticancer agents in melanoma, colorectal cancer, etc. (Miyazaki et al., 2010; Cheeseman et al., 2016; Evelyn et al., 2016; Foda and Neubig, 2023; Ma et al., 2024). The gene discussed is PIR; the disease is cancer.