Given the findings in the 5XFAD mouse model, we next determined whether there were alterations to the synaptic tau interacting proteins, SYNGR3 and LRP1, by western blot in the temporal lobe tissues of control, AD-Sz, and AD+Sz, where we have previously found increased phospho-tau in AD+Sz compared to the AD-Sz group (27). This evidence concerns the gene MAPT and Alzheimer disease.