Three of them were gonadotroph adenoma, 3 corticotropic adenoma, 3 GH and prolactin producing pituitary adenoma, 2 were plurihormonal pituitary adenoma, 4 with atypical sparsely granulated GH-producing pituitary adenoma, and 1 patient was not categorized into it. The gene discussed is GH1; the disease is functioning gonadotropic adenoma.