Six patients had GH-secreting pituitary adenoma, 4 patients had ACTH-secreting pituitary adenoma, 3 patients had GH-secreting pituitary adenoma and secondary hypothyroidism, 1 patient had FSH-secreting pituitary adenoma, 1 with hypogonadotropic hypogonadism and secondary hypocortisolism, 1 with ACTH-secreting pituitary adenoma and secondary hypothyroidism, 1 patient had GH-secreting adenoma with secondary hypothyroidism, hypocortisolism, and hypogonadism, and 2 patients had normal pituitary function. This evidence concerns the gene POMC and isolated thyroid-stimulating hormone deficiency.