Recent studies have suggested that volume-based parameters obtained via68Ga-PSMA PET/CT, such as PSMA-derived tumor volume (PSMA-TV) and total lesion PSMA (TL-PSMA), can reflect the tumor burden of PCa patients, and thus, may provide more accurate results in the evaluation of prognosis and monitoring of treatment response.6 This evidence concerns the gene FOLH1 and posterior cortical atrophy.