During inflammation, cytokines are released and they upregulate GLUT-1 on activated inflammatory cells.6This enhances the uptake of [18F]FDG during infection and inflammation, therefore can aid in assessment of sarcoidosis, tuberculosis, occult infection, autoimmune fibrosis, pneumonia, cystic fibrosis, and acute respiratory distress syndrome.7 The gene discussed is SLC2A1; the disease is infection.