1: One or more points on ESSDAI’s pulmonary domain; 2: At least once during follow-up; *mean ± SD; **median (interquartile range); *** reference values in appendices; ◊: At least once during follow-up; ANA: Antinuclear antibodies; Anti-SSA: Anti–Sjögren's syndrome-related antigen A; Anti-SSB: Anti–Sjögren's syndrome-related antigen B; ESR: Erythrocyte sedimentation rate; ESSDAI: EULAR Sjögren's syndrome disease activity index; NS: Non-significant; U: Mann-Whitney U test statistic; χ2: Chi-square test statistic; Z Standardized value associated with the Mann-Whitney U test. The gene discussed is BTG3; the disease is Sjogren syndrome.