In our study, the side effects were observed as enlargement of the nevi in two patients, two patients with knee pain, one patient with clavicle enlargement, two patients with an enlarged nose, three patients with hands and feet growth, one patient with eardrum perforation, two patients with enlargement of pituitary adenoma, and one patient with increased CA marker who received GH treatment. The gene discussed is GH1; the disease is pituitary gland adenoma.