The severity of the condition can range from mild elevations in creatine phosphokinase (CPK) to medical emergencies, such as compartment syndrome (CS), intravascular fluid depletion, disseminated intravascular coagulation (DIC), pigment-induced acute kidney injury (AKI), and cardiac arrhythmias [2,3]. The gene discussed is PIK3C2A; the disease is acute kidney injury.