APC and venous thromboembolism: The addition of TM would result in a broader testing of the APC pathway, although it would also be expected to have more interference from other coagulation processes upstream of the formation of thrombin, and he level of protein C. Additionally, Zermatten et al. previously suggested that the addition of TM to the TG test could be a promising tool to identify women taking combined oral contraceptives at high risk for venous thromboembolism, for example due to an unknown FVLeiden mutation (32).