In this study, it was observed that ID1-expressing macrophages maintain the pro-tumoral phenotype of TAMs and hinder infiltration of CD8 T cells into the tumour microenvironment by inhibiting Signal Transducer and Activator of Transcription 1 (STAT1) signalling mediated by SerpinB2 and CCL4 transcription (32). The gene discussed is SERPINB2; the disease is neoplasm.