To examine the receptor/ligand pairs that mediate NK cell recognition and killing of LCLs with both latent and lytic EBV infection, lysis assays were performed in the presence of blocking antibodies directed against NKG2D or DNAM-1; in addition, pan-HLA class I specific antibody (IgM clone A6136) was added or not during the lysis assay. This evidence concerns the gene CD226 and Epstein-Barr virus infection.