Tumor-educated neutrophils activate the AKT and p38 pathways in mesenchymal stem cells by secreting inflammatory factors (including IL-17, IL-23, and TNF-α), facilitating their conversion into cancer-associated fibroblasts (CAFs), which promotes the proliferation, migration, and invasion of gastric cancer cells in vitro and accelerates their growth and metastasis in vivo. This evidence concerns the gene IL17A and neoplasm.