The results of the immune system disease subgroup analysis (23–26, 28, 29, 31, 32), revealed that in the autoimmune disease group, the SIRT1 concentration in the case group was 1.46 ng/mL higher than in the control group (WMD, 1.46 ng/mL; 95% CI 0.16, 2.77 ng/mL; P= 0.027; I2 = 99.5%). The gene discussed is SIRT1; the disease is autoimmune disease.