SIRT1 and immune system disorder: The results of the immune system disease subgroup analysis (23–26, 28, 29, 31, 32), revealed that in the autoimmune disease group, the SIRT1 concentration in the case group was 1.46 ng/mL higher than in the control group (WMD, 1.46 ng/mL; 95% CI 0.16, 2.77 ng/mL; P= 0.027; I2 = 99.5%).