However, MCD increased menthol-induced activation of TRPM8 on mouse dorsal root ganglion neurons and transfected cell line (Morenilla-Palao et al., 2009) and no effect of MCD was demonstrated on resiniferatoxin binding to rat C6 glioma cell membranes ((Bari et al., 2005). The gene discussed is TRPM8; the disease is central nervous system cancer.