Importantly, JUNB, a part of the activator protein 1 transcription factor family, has been implicated in a myriad of biological processes[56, 57, 58, 59] and disease pathogenesis, particularly in cancer.[41, 60] However, its role is controversial, and has been classified both as a tumor suppressor[61] and an oncogene.[41, 42] Our findings introduce a concept that O‐GlcNAcylation may fundamentally alter cellular activity of JUNB, shedding new light on the connection between metabolism and stress response. Here, JUNB is linked to neoplasm.