CLEC4D and colitis: Studies have shown that the loss of the C-type lectin receptor Dectin-3 (Dectin-3−/−) leads to increased colorectal tumorigenesis and a greater burden of Candida albicans during chemically induced colitis.185 Elevated Candida albicans loads trigger macrophage glycolysis and IL-7 secretion, which, through the aryl hydrocarbon receptor and STAT3 pathways, induces RORγt innate lymphoid cells (ILC3s) to produce IL-22.