Dectin-3 induces MINCLE expression and forms heterodimers with dectin-2 to increase signaling and immune responses.120,121 Mice lacking dectin-3 exhibit severe colitis, reduced Th17 cell numbers, and increased Candida tropicalis burdens.122 These findings suggest that dectin-3 maintains gut epithelial integrity and controls fungal burdens and inflammatory responses by regulating macrophage phagocytosis and Th17 cell numbers. Here, CLEC4D is linked to colitis.