CLEC7A and fungal infectious disease: Mouse model studies have revealed that dectin-1 provides protection against fungal infections in systemic candidiasis112 and in the skin,108 oral cavity,113 gut,102 and lungs.114 Human studies also indicate that mutations in the dectin-1 gene CLEC7A reduce dectin-1 expression, impairing cytokine production and predisposing individuals to recurrent vulvovaginal infections.115 The role of dectin-1 extends beyond local defense; during fungal dysbiosis, dectin-1 regulates antifungal immunity to prevent the overgrowth of opportunistic fungi such as Candida and Mucor.