Copper enhances tumorigenesis by activating the PI3K‐PDK1‐AKT signaling pathway in a SLC31A1‐dependent manner, and Nedd4L‐mediated ubiquitination as an upstream negative regulator of SLC31A1 acts as a tumor suppressant by inhibiting the SLC31A1‐PDK1‐AKT oncogenic pathway [9]. This evidence concerns the gene PDK1 and neoplasm.