However, cohorts of asthenozoospermic patients have subsequently been screened for SLC26A8 immunostaining [46, 47] and the proportion of patients with defective immunostaining of the annulus was found very low (1/75 and 3/254, corresponding to 1.2% of the cohorts), suggesting that annulus abnormalities remain a rare event in human asthenozoospermia. The gene discussed is SLC26A8; the disease is Reduced sperm motility.