Finally, patients with mutations of both SLC26A8 alleles have also recently been identified; this is the case of two patients with compound heterozygous mutations (c.290T > C,p.Leu97Pro/ c.1664delT,p.Ile555Thrfs*11 and c.290T > C,p.Leu97Pro/c.212G > T,p.Arg71Leu) displaying severe asthenozoospermia (total motility 4.8 and 8.7%, progressive motility 0.6 and 0.4%, for the two patients) [56]. This evidence concerns the gene SLC26A8 and Reduced sperm motility.