Further, cellular senescence mediated by p21WAF1/Cip1 is suppressed by the lncRNA GUARDIN through a LRP130-PGC1a-FOXO4 signaling axis in various cancer types [51] whereas p21WAF1/Cip1 plays rather an ancillary role in inducing SAL-mediated senescence in PCa. Here, PPARGC1A is linked to posterior cortical atrophy.