We found that MIR503HG expression is upregulated in metastatic PCa tumor compared to primary tumor and normal tissue and is correlating with poor survival of patients with prostate adenocarcinoma suggesting an oncogenic function of MIR503HG. Functional assays revealed that MIR503HG promotes the growth of PCa cell lines and 3D tumor spheroids and inhibits the induction of the SAL-mediated cellular senescence indicating rather an oncogenic role of MIR503HG in PCa. Here, MIR503HG is linked to posterior cortical atrophy.