BRCA2 and posterior cortical atrophy: Interestingly, in line with its oncogenic activity, MIR503HG upregulates the SAL-repressed homology-directed DNA repair gene BRCA2. Since SAL represses the expression of the lncRNA MIR503HG it may support mechanistically the use of PARP inhibitors and suggests that MIR503HG is involved in homology-directed DNA repair in PCa cells.