MIR503HG and posterior cortical atrophy: Interestingly, analysis of the SA β-Gal activity showed a strong increase of senescent cells following MIR503HG knockdown in LNCaP (Fig. 2E, F) and C4-2 cells (Fig. 2E, G), indicating that MIR503HG functions as critical suppressor of SAL-induced cellular senescence in PCa cells.