IFNA1 and influenza: Consistently, Ingenuity Pathway Analysis (IPA) revealed that five pathways were significantly enriched by IFN-I stimulation both in WT and ACSL1M−/− BMDMs; IFNα/β signaling, IFNγ signaling, pyroptosis signaling pathway, role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza, and macrophage classical activation signaling pathway (Fig. 3B, C).