MTHFR and hyperhomocysteinemia: Hyperhomocysteine is also linked to impaired nerve function due to oxidative stress.Methylenetetrahydrofolate reductase(MTHFR) catalyzes the transformation of homocysteine into methionine through the remethylation pathway; however, a decrease inMTHFRactivity due to mutation increases the chances of hyperhomocysteinemia.8, 9, 10, 11