Porphyromonas gingivalis, Fusobacterium nucleatum, and A. actinomycetemcomitans are pivotal pathogens in periodontitis, and the resulted elevation levels of pro‐inflammatory biomarkers such as C‐reactive protein (CRP), interleukin (IL)‐6, and IL‐1 contribute to the exacerbation of stroke by promoting neuroinflammation [64, 65]. The gene discussed is CRP; the disease is periodontitis.