CRC studies reveal that Fn induces M2 polarisation by activating the TLR4/NF‐κB/S100A9 cascade, wherein a proinflammatory microenvironment is established following S100A9 release to potentiate the ability of malignant colorectal cells to metastasise ultimately.59 This evidence concerns the gene NFKB1 and colorectal carcinoma.