By modulating the function of ITGB3, ITGB3BP affects crucial cellular activities, including wound healing, tissue regeneration, and immune responses.52,53 ITGB3BP participates bilaterally in cancer development, functioning as a tumor suppressor or promoter.54 Hence, it is central to the cell adhesion network and signaling pathways, critically mediating cellular functions essential for development, homeostasis, and disease progression. The gene discussed is ITGB3; the disease is cancer.