Synaptopodin is expressed in kidney pseudopodia and the nervous system where it is essential for spine formation in telencephalic neurons.74 It also plays a role in epithelial cell apical stress biology.75 Elramah et al.76 recently demonstrated in a mouse model of cancer pain the upregulation of synaptopodin by downregulation of miR-124, an endogenous inhibitor of synaptopodin. Here, SYNPO is linked to cancer.