HSF2 encodes a heat shock factor (HSF) protein, heat shock transcription factor 2, and is highly expressed in the brain.113 HSF2 is a transcription factor involved in chromatin condensation, regulation of the cell cycle121 and is activated by hemin rather than heat.121 Additionally, HSF2 also activates the transcription of genes in response to oxidative stress, similar to what is seen in acinar and duct cells122 making it another candidate for studies of pancreatitis pain (see also Colocalization results, below). Here, HSF2 is linked to pancreatitis.