After spinal cord injury in rats, RGMa blocking antibodies promoted neuronal survival, and enhanced the plasticity of descending serotonergic pathways and corticospinal tract axonal regeneration.79 In mice with peripheral nerve injury, Reg3b (REG3A in humans) is transported to the spinal cord where it activates spinal microglia.91 Reg3b appears to maintain neuropathic pain by proinflammatory effects on microglia.91 Further studies on the effect of variants in specific REG genes related to pancreatic inflammation (with or without cancer) and neuropathic pain are needed. This evidence concerns the gene REG1A and neuropathic pain.