NEURL3 and pancreatitis: NEURL3, neuralized E3 ubiquitin protein ligase 3 formally known as LINCR, is involved in protein ubiquitination and is primarily expressed in salivary glands and pancreas.57,96,113 NEURL3 is also involved in cellular mechanisms involved in spinal development.118,119 Increased expression of NEURL3 is reported in lung tissue in response to inflammation from endotoxemia.120 Genetically altered expression of NEURL3 in response to inflammation may be important in the pathophysiology of patients with constant pancreatitis pain.