This represents the first systematic genetic analysis of pancreatitis pain loci, complementing and extending the candidate gene studies for depression, anxiety and PTSD.13,14 More compelling are the 4 genes linked to the BDNF neuropathic pain pathway (SNYPR, NTF3, DOK6 and RBFOX1) with elevated BDNF levels in pancreatic pain patients. Here, RBFOX1 is linked to major depressive disorder.