This represents the first systematic genetic analysis of pancreatitis pain loci, complementing and extending the candidate gene studies for depression, anxiety and PTSD.13,14 More compelling are the 4 genes linked to the BDNF neuropathic pain pathway (SNYPR, NTF3, DOK6 and RBFOX1) with elevated BDNF levels in pancreatic pain patients. This evidence concerns the gene BDNF and depressive symptom measurement.