Agreeing with the proposed role of these lipids in driving arterial coagulation in vivo, Alox15−/− mice, which lack many eoxPL, generated smaller thrombi in an arterial model of AAAs (15), and higher levels of eoxPL are associated with prothrombotic autoimmunity (8). The gene discussed is ALOX15; the disease is achalasia-alacrima syndrome.