Although FKBP5 single nucleotide polymorphisms are linked to increased susceptibility to stress-related disorders, like depression in humans,28, 29 they also increase responsiveness to antidepressants,30 likely due to altered regulation of autophagy pathways.31, 32 Interestingly, there is growing evidence to support a regulatory and reciprocal role of circadian rhythms on the function of autophagy.33, 34. The gene discussed is FKBP5; the disease is major depressive disorder.