Variants of the FK506-binding protein 5 (FKBP5) gene that can potentially increase the levels of the FKBP51 protein have been implicated in numerous psychiatric disorders, including PTSD.13, 14 FKBP51, in part, is involved in regulating glucocorticoid receptor (GR)-mediated stress response via its interaction with heat shock protein 90 (Hsp90).15 Here, NR3C1 is linked to psychiatric disorder.